To get a response from American Airlines, you can try several methods. The most direct option is to call their customer service at 1-800-433-7300, where you can speak with an agent after following the automated prompts. Alternatively, use their live chat feature on the American Airlines website or app for quick, real-time assistance. You can also reach out via social media, such as Twitter (@AmericanAir), where they are often responsive. If your issue is urgent, visit an airport ticket counter. For email inquiries, expect a slower response, but ensure you provide clear details for quicker resolution.